I have been on Latuda for a few months now. After yrs of trial and error and unrelenting depression, I am extremely grateful to have finally found the missing ingredient in my med cocktail i was originally prescribed 20mgs take am after eating. The first few days were HELL! I was nauseous, muscle pain and fatigue during the day, eating everything sugary in sight, early afternoon into evening, agitation ,irritability, and loopy feeling mental fog would set in, night was hell too insomnia, hot and cold sweats, nightmares, EXTREME thirst... I almost just threw the damn bottle away! But I could not stand the thought of going through yet another med fail and having to rework up the courage to try another AGAIN.... So I called my Doc and explained my side effects and asked what she thought. She said sounds like overdose symptoms take a few days off to get back to base and then try again start with half and move it to night. Long story, short..... (Lol) I can't remember EVER feeling this healthy and balanced! I'm so glad that I didn't give up on it. I still get mild side effects but compared to the benefits they are nothing " Technically" I am not even on what is considered a therapeutic dose but I am very sensitive to meds and.... Hey if it ain't broke....!