I was on 100mg of desvenlafaxine (pristiq) which is essentially an active metabolite of Effexor. It made me much much worse & became mixed. I ended up starting Prozac the day I stopped pristiq in the end, it risks serotonin syndrome but I never had any symptoms suggestive of it when taking 50mg pristiq (I had to drop to 50mg for a few days prior) & 20mg Prozac together. Prozac has an extended half life & so doesn't totally leave the system for something like 6-8 weeks which helps with discontinuation syndrome. Prozac is often used like this from what I understand. Maybe an option but Prozac made me hypomanic aswell.