I recently smoked weed and had no problem feeling it but it made me paranoid, so not doing that again. I've only experimented with coke in my teens but I'd be too afraid to do it now since I've went through a psychosis. I think you'd still feel the effects. I don't think it's good to be mixing psych meds with street drugs all the time though. But if it's every once in awhile and your stable who am I to judge....