I would have to agree that it is specific to the individual. I love being on Wellbutrin, but I've heard that makes others manic. Effexor seemed to work for me in the very beginning, but I don't think it's doing anything now. I gained a ton of weight on Seroquel, so I refuse to go back on that, but some take it for sleep. Everyone has different body chemistry so what works one may not work for the other. That will be something you have to work with out with your pdoc.