Things that release or inhibit norepinephrine make me feel anhedonic like how anxiety makes you feel nothing during a panic attack.

When I started Concerta, It made me feel so terrible. It increases norepinephrine and I felt good when it wore off so I stopped taking it for 3 months.

Then I abused it and it increased the tolerance at a faster rate. My psychiatrist said it would take 3 months for the anhedonia to go away and I couldn't wait that long. Then I started to like it eventually because my brain adjusted to it. Effexor IR is like crack so they discontinued it I think.

I think that's why the ADHD med (Strattera) has the main side effect of suicidal thoughts which is why most people stop taking it because it's an NRI.

@Ody, I think you have to wait until your brain adjusts to it.. then you will need it to feel hedonic.. so I wouldn't take it for like 10 years. For me, it would take years to decrease the tolerance.

But norepinephrine is stimulating and the brain never forgets the path of stimulants.