I just started on Lamictal about a week ago. My p-doc is having me do 25 mg for 2 weeks, then 50 mg for 2 weeks, then up to 100 mg. Going up slowly like that apparently decreases the chance of a really bad, but rare, skin reaction. (She did say if I had any strange rash to let her know immediately.)

I'm not sure I've felt much of an effect from it yet. I'm also on Zoloft (150 mg) and am trying Lamictal because we're wondering if I actually have bipolar II (rather than recurring major depressive episodes plus anxiety). Haven't noticed any sleepy or sedating effect--or other side effects really, though I have had a few headaches (might not be med-related). Will update if I notice anything once I go up in dose.