I've been taking 20 mg twice a day for about a year. I know that is a high dose but I worked up to it. I've been taking it for about 6 years. My doc took me off as he saw no more anxiety but once I went to the ER for something completely unrelated, I had this monster panic attack and they had to treat my anxiety before tending to my physical ailment which turned out to be an ulcer. The ER doc put on my follow-up paperwork that I was extremely anxious and needed to be medicated, so I was put back on last Spring. It isn't sedating for me at all. Well, if I take 2 it is but I don't do that. Once I did that and I ran out early and you cannot refill those until time is up. I take Seroquel at night for psychosis and sleep. It really works for both.