My Dad titrated up 25 mg every two weeks like the others have mentioned. He started out only taking it in the AM as it is activating until he got to higher dosages but now it is split is 150 mg in the AM & early PM another 150 mg.

He started to notice some effects at around the total dose of 200 mg for him but every one's body chemistry is so different it is hard to say what will be the case. It could be at a much lower dose or even higher dose before effects are felt, if at all.

I hope you find the medication that works for you soon.