I'm about to head out to the garage to use a little right now. For good or bad I can't really say it has had a negative effect on my moods, quite the opposite. When I am up and flying the weed definitely helps me relax and sleep. When depressed or mixed it gives me a little reprieve from the madness and helps me to re center myself. That being said, I'm in the process of weaning myself off because I use it more than my healthy coping skills to deal with mood swings. Too bad I love the stuff and it's still illegal medically and otherwise here.