I've been taking St. John's Wort for about a month now. Should it have had an effect by now? And how strict is it generally with application times? With three times a day my timing does vary from day to day. Sometimes I take the first two together, even, although that's probably not great. But yeah. How finicky is it about when you take it? And how can you tell if it's working? I had a pretty bad day for the depression just two days ago, which was discouraging.