I was on 400 mg (slowly built up from 50) some years ago. I slept good; I put on sixty pounds; and I seemed to be somewhat level, if a bit sluggish at times. Fast forward some years to the present, and the doc again gave me Seroquel, though I fought him tooth and nail (I cannot stand to put that weight on again). This time, he told me to take it only for sleep; yet another mixture in my ever-evolving cocktail of drugs. I tried it whole, as he directed, for twelve hours of sleep. I tossed and turned, and finally got up. The next night, I broke it two, as he suggested, and expected a full eight hours of sleep. All I got was four hours sleep and the zombie-like sluggishness, which has to be a Seroquel hangover. I don't know if my body changed, or what, but now this medicine seems a bit useless to me.