It depends on the MI and its severity.
I've been diagnosed with Depression and PTSD.
I have avoided doing everything I didn't want to do. I think I have ADHD as do many in my family.
I am very dedicated and responsible when I am interested in what I am doing. I've been successful in several different careers; performing arts, retail, non-profit org, agent/broker. I didn't stick with doing just one thing, I keep growing and changing, but successful at each step.

Yes, I have had bouts of depression that got in the way of work at times.