It seems that scopolamine makes my depression and brain fog go away instantly. Scopolamine affects acetylcholine. It is for motion sickness and is not approved for depression in the US yet. Several studies have shown that scopolamine is very effective for people who do not benefit from the serotonin antidepressants.

Several questions:

(1) Why hasn't scopolamine been approved for depression yet? Scopolamine is a very old motion sickness medication. Are there some dangers to scopolamine?

(2) Are there approved depression drugs that affect acetylcholine instead of serotonin?

(3) After I experimented with some leftover scopolamine patches for a couple of weeks, I noticed some changes, but I don't know if they were coincidence. So as I mentioned earlier, the scopolamine instantly made my depression and brain fog go away, but the patches only lasted three days. I stopped using the patches after a couple of weeks, because I wanted to save the remaining patches for emergency use. Then a week or so later some things changed that might have been coincidental. My libido had been practically non-existent for almost a year, but it suddenly went back to its previous level. I got sick with the flu (that may have been stress due to things in my life). I also had a breakthrough in therapy and suddenly saw a purpose to a life that I had basically written-off for the past 15 years. All my bitterness vanished. For several weeks I felt very sad and drained, but I also felt that my life was going to take a turn for the better now. I found that I could meditate almost effortlessly again where I had not been able to for several years. ... Then it all changed back to how it has been for the past year. My libido is non-existent. I don't feel as hopeful about my life. I feel cynical and unemotional. ... So I don't know if that was scopolamine or just a coincidence. I also worry about using scopolamine if it had such a dramatic affect on me. My brain must be really unbalanced chemically if such a common drug for motion sickness can do these things.

Any thoughts would be appreciated. I think I have some useful clues, but I don't know how to proceed from here. I am afraid of taking medications due to past experiences. Thanks.