Zyprexa (regular) makes me gain weight. I gained 35lbs in 2 months when I was first on it!! And it had nothing to do with diet or exercise -- I didn't eat any differently or exercise any differently. It was purely the Zyprexa, which unfortunately isn't uncommon.

What I take now though is Zyprexa Zydis. For whatever reason, the Zydis version doesn't make me gain weight, so now when I need to be on Zyprexa, that's what I take because it's just as effective but for me has 0 side effects. Weight gain is the reason I went off Zyprexa in the first place.

So I guess all that rambling comes out to: If you gain weight from the regular stuff, dont' give up on it before you try Zydis. My pdoc said I'm not the only one she knows who gains weight from the regular but not from the Zydis, so there has to be something different about it.