Here is an article I found about the effect of scopolamine on acetylcholine in rats. It is especially interesting, because the effect peaks after 1 hour and dissipates in 3 hours. This is very close to what I observed when using myself as a human lab rat
I felt great in a half hour or less. I had boundless energy. I wanted to find ways to make other people happy. I got lots of work done in no time at all. "Excuse me while I kiss the sky" might be a close description of how I felt. But it tailed-off in a few hours until I felt "normal" (i.e. depressed).
I have been wondering if this means I am missing some vitamin related to acetylcholine. Here is the article, but I don't understand what it means. I don't know if my response means I have too much acetylcholine or too little or not in the right brain regions or what. Maybe somebody can enlighten me?
Quote:
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The in vivo microdialysis technique was used to measure extracellular concentrations of acetylcholine (ACh) in the neostriatum (NS) and nucleus accumbens (NAc) of freely moving rats after intraperitoneal administration of the muscarinic receptor antagonist scopolamine (0.5 mg/kg) or vehicle. Simultaneously, behavior was monitored. The administration of scopolamine induced an increase in extracellular ACh levels in the NS, which reached a maximum of about 185% within one hour after injection and returned to baseline values about three hours after injection. In the NAc, an increase of similar time-course was observed; however, this increase reached a maximum of 250%, which was significantly higher than the one observed in NS. These changes in ACh levels were accompanied by enhanced locomotion, rearing and grooming; however, the behavioral changes were of shorter time-course than those of extracellular ACh.
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Different effects of scopolamine on extracellular acetylcholine levels in neostriatum and nucleus accumbens measured in vivo: possible interaction ... - PubMed - NCBI