Always take it with food. Geodon is different than a lot of meds. Usually when a drug is supposed to be taken with food, it is to help from making your stomach upset or whatever.

If you take Geodon on an empty stomach it will do nothing for you. You might as well not have taken it.

Its bio-availability depends on what you just ate. The more calories you just ate(up to some limit I am not sure of) the higher percentage of the drug will get absorbed into your system.

How many times a day depends on what your prescription says.