Day one of Wellbutrin, can have me feeling the beginnings of hypo the very next day. Yes! Stay on it a week, and I might as well be doing lines of Coke all day long. No joke. For me, mania feels very similar to using stimulants. (I've experienced several stimulants which have this effect). Right now I'm hypo (for about a week). I'm not taking meds, no caffeine or anything, and I feel VERY stimulated. I'm sensitive to meds, but I doubt I'm the only one whose experienced this? I've taken it several times to test the theory.