I'm new to this site. Barbella, I haven't been diagnosed with treatment resistant depression by my psychiatrist, but I think it must be what I have. I have been on several different medications over the past few years and it's so discouraging, isn't it? I start a new medication and rock along thinking THIS one will finally work and I will feel like my "normal" self. Sometimes, I will have a side-effect like increased blood pressure, and have to discontinue the medication. If not, I will be okay for a few weeks or months. But slowly, I sink back into depression. Right now, I am on a newly increased dose (100 mg) of generic Zoloft. I feel normal, in control, have no problems sleeping or finishing tasks and I'm full of hope. I'm not a negative person but I am cautious about making long-range plans because I don't want to have to cancel them and disappoint others and myself. It's a struggle, isn't it? I'm glad I found this site and plan to visit often. Blessings to you.