I'm on 5 myself, uppers and downers as well. I was actually just talking with some people today about how many meds I'm on and how depressing it is to me that I have to be on 5 different meds taken at 3 different times a day just to come close to being "stable". and in all honesty all they really do for me is make the symptoms less severe, and not by all that much. I'm close to asking my pdoc for more information on ECT, but that wont even be an option until I finish my degree due to the potential memory loss...