I've been on Lamictal and the generic lamotrigine. My pdoc considered the theraputic dose for mood stabilization to be 200mg. The first time around I couldn't tolerate more than 150mg of Lamictal without getting debilitating headaches. Switched to valproic acid for a few years until the generic was available. I tolerated 200mg of lamotrigine--no headaches. That worked well as a stabilizer for a couple years. Then I had a couple of weeks where I missed a dose here and there which resulted in 3 nights of no sleep and a panicked upward swing. Went up to 300mg daily--150 in the morning and 150 at night. That's been good so far, but I noticed I get very irritable if I take my morning dose even a few hours later than usual.