Before reading on, please understand this is not intended as criticism but merely to increase understanding. When you say he has "played" with many med combos you make it sound like it has not been a serious effort. It's important to understand that it can take many tries before finding a treatment that works since everyone reacts to medications differently. But it is equally important for him to see a doc regularly and stick to the prescribed regimen. Also, please try to understand that his depression is something over which he has no immediate control. Medication and therapy may help, but it's not something one can "just snap out of". I know how hard it is for you to be at the receiving end of this but it is equally hard to be him. The best advice I can give is to educate yourself about his situation and communicate your distress. You may find he is not wholly unaware of the effects the situation is having on you.