My depression started last June when my pdoc and I wanted to go off Venlafaxine and try fluoxitine(I felt the best on it but that was 15yrs ago). Well I have been suffering every since then. I went back to my old dose of van and had Abilify added to my meds. No change. Scratched Abilify and tried Latuda. Developed hives at 40mg. Stopped that tried 300mg of quetiapine at night. It knocked me out for 9hrs. I liked that vs waking 2 or 3 times a night. But it has barely affected my depression. I've been on it since the end of January. I can't deal with all the family problems and financial difficulties among other issues I need to deal with sooner rather than later. Do I call my pdoc and tell him this just isn't enough improvement. I've always been a "take the least dose" kind of person but right now I want out of this hell! The meds I take are:

Venlafaxine 150mg x 2
Lamotrigine 150mg x 2
Quetiapine 300

Levothroxine .88mcg (post op thyroidectomy)
Atenolol/Clorthalidone 50/25
Simvastatin 20mg

Gained alot of weight resulting in high blood pressure and cholelestorol.