When I was on pills I would skip them if I was planning on drinking. I don't think I ever experienced anything negative but I was also inevitably hungover the next day so...yeah. The only led I could never skip was Effexor. Withdrawal from that is awful.

Now I'm on a monthly injection and a patch so I don't skip. And I'm prescribed to put the patch on every other day so I end up spending a day off the patch anyway. So far it's been working for me.