I have been in the hospital several times, for what my neurologist calls serotonin syndrome. Anything that increases my serotonin levels will cause a severe reaction - including SSRI's (resulting in me spending days to week in the hospital). My reaction first occured when I mother passed away a few years ago, and I was placed on an anti-depressant. After two more incidents from various other medications, I have a long tedious list of different medications that I cannot take. My most recent problem is that after my one year anniversary my therapist insists that I am once again experiencing major depressive symptoms. She has suggested that I go on medication once more, but she is not able to prescribe me anything. She suggested that I go to a psychiatrist about getting a prescription, but after my previous episodes with serotonin, it seems useless. Is anyone aware of a anti-depressant that will not affect the serotonin levels of the brain? Or is that essentially the point? Thank you very much in advance for your help.