I tried one day without antipsychotics or supplements. Just one day. Actually half a day (including the night). I don't jump to conclusions, have epiphanies, but I do have a feeling of dread and feel stuck, more than usually, not extreme, but debilitating enough.

I haven't tried any high-dose supplements/substitutes (which includes nicotine). I'll now use 5-HTP, more nicotine, acetylcysteine and vitamin E, to see how the rest of the day goes.

Such problems are usually strongest in the evening, regardless of when I take my antipsychotic, so I'll at least have to use all these substances again one day, at night, without antipsychotics.

Edit:
Important to note, but what can be expected, I don't expect a positive effect (I am questioning whether my supplements are poisoned, to give you an idea).

Another edit:
I forgot to mention methylfolate and methyl-B12. Quite a lot. Likely to be important together with the rest. A link in the chain. Maybe.