I just started taking L-theanine and it's awesome. I have trouble sleeping (night shift worker) and have added L-theanine and 3 mg melatonin to my clonopin and doxepin and I am sleeping really well, all things considered. I also take D3 2000IU and "Calm Tabs" from Puritan's Pride which have a bunch of herbal things, as well as Sertraline for depression. I am going to add milk thistle/silymarin as I worry about the damage I am doing to my liver. I try to check drug interactions in medical papers and so far have not found anything worrying yet.