Thank you all for your replies. I am taking my Xarelto as prescribed. I just wish depression was as easy to treat as blood clots. Yesterday I was able to get some things done around the house, like fix the sprinkler system, replace our front door handle and make dinner. I also went on a two-hour bike ride. Today I woke up at 2:30 and my mood is tanking. I'll just have to gut out another day, as Skeezyks says.