Well .... This is tricky situation as for right now its kinda damned if you do and damned if you don't.
Yes partners should be there for each other .. But there are limits..
If she is having trouble with feeling down alot then she would benefit from seeing a therapist....
Hard to do but a sit down and agree to calmly discuss the problems really needs to happen. In the past when things were really hard for my husband I to verbally discuss we actually emailed each other, it helped in a couple ways. For one we could hit that backspace button and we were able to get everything out we wanted to say and then the other was given time to think and respond. Once things were really out in the open we could sit down and focus on what the real issue was not the "in the heat of the moment" stuff
She needs to understand that you have a job and need to rest to be able to do your job. does she work?
This should kinda fall into " unless the house is on fire most everything can wait until you can both discuss things.
Welcome to PC