Yes, people, i have gained weight on Seroquel. But i look on the bright side: Seroquel arouses my appetite and sharpens my palate so much that food is an incredible source of pleasure! I can almost feel the dopamine dumping into my brain after a good meal. I call it my 'food high.' Just like a heroin junkie after a hit, i am content to sit quietly and watch the world go by if i'm at the mall or watch benign mainstream TV if i'm home. Such a pleasure!