I've been on medication since my freshman year of high school, when they started me out with Prozac, so I've been tweaking my medications for the past four years. It turned out that the only thing that Prozac did to me was make me not want to eat, so I lost a bunch of weight, much to the distress of my friends and family, and I got off the Prozac. My psychiatrist ended up prescribing me different medications, ones that I don't even remember now, and none of them worked. I went without medicine for a little bit, since my family and I moved soon after my freshman year ended, and I had to find a new pdoc. We found one, and he diagnosed me with bipolar disorder instead of depression like before. So he took the approach of mood stabilizers instead of anti-depressants. After flirting with Lamictal, Depakote, Topamax, Serequel, Klonopin, and countless others for a year and a half, we moved again and I started fresh with a new doctor.
By this time I figured I had a pretty good cocktail going, when in all truth I didn't, I just wanted to stop switching medicines all the time, since it was always pretty much every few weeks I needed to change it (and we all know how bad the first few weeks of a new med can be!). Then I tried several other medications. By this time I was fine-tuning the medicines I took so everything that got changed was pretty much upping the dosage, lowering the dosage, or adding on another symptom-specific medication. I ended up with Lamictal, Wellbutrin, Serequel, Topomax, and Buspar. I've been on that mixture for a while now, until lately when I cut my morning medicine, and now I take less Lamictal, less Buspar, and no Wellbutrin. That's been the case for the past two months or so, and so far I'm doing really well. I keep busy and confide in my family and my room mate. I'm not going to make any changes for a while now, since I'm doing well now.
But I don't know if this was any help, or if it even answered your question. Good luck with whatever you decide to do!