Zyprexa has made me gain about 30lbs since I started it a few months ago. I'm now currently at my heaviest weight ever...but I'm also more stable than I've ever been, so I kind of just have to deal with it. It's not about eating either. I eat the same amount, maybe less depending on how much I'm restricting (EDs and APs don't go well together). I gain on Zyprexa, and it doesn't help that I'm on Seroquel as well. Both mess with your metabolism.