There is some research on St. John's Wort that it can help with depression and iffy research on others. I take melatonin occasionally to sleep and it works well but I also need valarian root to keep my dreams from going too crazy. I have tried various things, especially for anxiety, none of which worked at all. I also take a lot of vitamins and other supplement to keep hormones from dropping. I take fish oil, B stress complex, C, D, ginseng, CoQ10, magnesium and fenugreek. Since I started on that my various hormone levels have more than doubled, still low but moving in the right direction. None of it help my MH issues, but it is making me more healthy otherwise. The suggestion for blood work is a very good one, thyroid, various hormones, iron and a host of other things can trigger depression and should be ruled out. If there is an underlying cause, treating that is the way to go.

The thing to keep in mind is that these supplements are not regulated and studies have shown as much as 1/3 of supplements contain things other than what the label claims. You truly do not know what is in the bottle unlike pharmaceuticals, which of course come with their own large list of problems.

That is not to say that they are worthless, you just need to do your research and be very careful of which brand you buy.