Yes. But I'm a newbie so no insight yet. Just got genetic testing done and I have the particular gene series that indicates that I need L methyl folate supplements basically for the rest of my life. I started Deplin 4 days ago and am trying to be cautiously hopeful, as I have tried pretty much everything else medication wise to no avail. I'm also entering a ketamine trial next month so hopefully one, the other, or both will finally give me some relief.