I've gained about 80 pounds on it. It makes me ravenously hungry and I tend to eat until I fall asleep almost every night. Tried Saphris - it helped with the hunger and I actually lost weight without trying. However, Seroquel has an antidepressant effect at doses of 300mg or higher, while Saphris does not, and I had to switch back to the Seroquel when I became depressed again. Can't take actual antidepressants anymore because they make me manic.