I've been through all the testing, even a colonoscopy. My mother had bowel problems all her life, then got colon cancer, had half her colon removed and has been symptom free ever since. About 15 years. I've had IBS since my early teens and when it got much worse about 8 years ago, I got increasingly worried because of my sons illness and moms history. They checked everything. They say it's anxiety. I didn't used to think that possible because it happens even when I don't think I'm anxious. But I've learned that anxiety can manifest as illness and that might be the case for me. I think it's a number of things. Eating right, getting more activity, controlling my anxiety and MI might be a good combo to stick with but I always fail and do something I'm not suppose to.