So maybe a couple weeks ago, there were a few posts in here about how exercise makes some of us feel worse instead of getting that endorphin high (I was one of them). Someone mentioned that they'd read about a genetic mutation that could affect how exercise affects you. For other reasons, my integrative doc had me do the 23andme genetic screening, which gives you a few reports on its own (like ethnic heritage), but then you also get a massive amount of raw data that can be interpreted through various sites. I got my report back today, and my doc had me upload the raw data to a site that mainly examines genes and mutations that affect methylation because she thinks i may have issues with it (have to wait for her to interpret that because there's a lot of stuff...)

One of the mutations that came up for me represents a deficiency in AMPD1. And it had this about it: "AMPD1 deficiency homozygous This is found in ~2% of all Caucasians. The majority of people with the AMPD gene are asymptomatic, but in response to vigorous exercise, others have symptoms including early fatigue, muscle pain and muscle cramping."

So...maybe that helps explain my issues with exercise/working out and lack of stamina? I feel strangely vindicated if that's the case... My H has said before that I shouldn't be as tired as I am after physical activity and seems to imply I'm lazy because I dislike working out (because it makes me feel worse, usually, and sometimes leads to increased anxiety/panic).

Here are some other links on it that were mentioned on the site:
http://en.wikipedia.org/wiki/Adenosi...iciency_type_1

http://rarediseases.info.nih.gov/GAR...eficiency.aspx