I just didn't respond to any treatment. I was on something like 900 mg Seroquel,10mg Zyprexa, 50 mg hydroxyzine every 4 hours, klonopin every 4 hours, valium, and maybe something else and I couldn't be still. I wound up on 1:1 in the hospital just to keep me from pacing all the time. Then I took benadryl which turns out to agitate me so it got even worse. I walked so much I completely wore out a new pair of slippers in just a few days. It was not pleasant. Nothing has ever felt as good as that loading dose and the nap I got from it.