Ooh, that's hard to say. Best in some ways, Nardil, because it was incredibly amazing... other than the fact that it made me gain 70 pounds and sent me into hypomania. More practical best, lamictal.

It's hard to say worst, because some I didn't stick on super long. Seroquel was like severe depression in a bottle for me, but I couldn't stand to try it more than a couple days so it may've gotten better. Parnate was the devil for me. Also Cymbalta or pretty much all SNRIs make me too sick and anxious.

I don't have a ton of options I haven't tried. For some reason I'm really curious about Geodon. Also wanna try Suboxone off-label for derealization/depersonalization.