I do, but it keeps me really sleepy the next day anyway (the "Seroquel hangover"). I'm also taking a higher dose than I'd like which I already lowered a bit on my own. My pdoc said I need to keep taking it at that dose for 8 weeks after my depression to keep it at bay (according to recent studies he's read re Bipolar depression). I see my pdoc soon and will discuss nixing it.