I'm sorry that your going through such a rough time.
I don't know if any advice I can offer will be helpful. But I will try.
People change in many ways, Yes parents should always be supportive and there when you need them, But they are people also and probably have stress that you don' even know about and could be something that you had no need to ever know, I would imagine that there is stress because of your older brother that has CP , I know as a parent I would be worried about my child's future if I were not there.
As for your twin... I'm really at a loss as I have no idea what having a twin is like, the few people that I have known through out my life that are twins do share a special bond.... But eventually each person has there own life and i'm sure it feels like he just doesn't care and is moving on without you ... I think you both need a life of your own.
The interaction that you had with that girl ? Its promising , You just need to get out there and go after the life you want, mentally I think you would do yourself a favor to set aside your feelings about your twin and how your not getting the support you would like from your parents. Get out and start seeing people and doing things and date some girls. Build your self esteem up. Yeah yeah it isn't going to happen overnight but you have to start somewhere and I think you should start with YOU
I'm sorry in the past you haven't gotten alot of feedback and advice , Sometimes people just don't know what to say .. It happens to everyone.. Hopefully more people can read this and offer you advice that I am not thinking of..
Be kind to yourself
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Helping others gets me out of my own head ~
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