For me, life experience depression/"why am I here" sorts of questions come up when a change is needed or after a big shake-up. I'm 65 and my husband passed away back in October and I moved to a retirement community, very big changes and now that I'm settled in and have traded in my too big car for something smaller I like and swapped out all my furniture, I'm looking around for "what's next" and getting a lot of the grief I put on hold during the last six months.
If you can, look positively at the discomfort, it's trying to help, like a bad dream sometimes does, gets you looking harder at what you want, what feels "wrong' or stale, etc. It can help consolidate and give you closure to periods of your life, tell you when it's time to "leave" :-)
Any yearning to travel or teach or design/fix electronic instruments?

Does anything like Best Buy's, store-within-a-store ("experience centers"):
Forbes Welcome excite you? Any yearning to design phone apps or games? Any project you have been kicking around for the last 10-20 years, daydreaming about?