Seems like I always end up back at square 1. Just where I started. I change meds and they work good for about a year, then begin to lose effictiveness. When I go up on the dosage my blood pressure gets out of wack. I change meds again and it starts over. I'm trying to hang in there with my current med, Cymbalta, but it seems to be getting worse. Feel like I'm almost back to where I was before I was diagnosed. Does it ever end?