I noticed each med as I added them (well maybe not Lamictal for depression--but my pdoc likes it for mood control). I was on Seroquel but it gave me waking-up-in-the-night joint pain. I switched to Latuda which stopped that but gave me bad akathisia so we added propranolol till we got up to 80mg and that cured that. For sleep I had Ambien but it wasn't great. Switched to Lunesta which was better but not enough. Then I asked for 50mg of Seroquel to add and that works (no joint pain at that dose). Finally for the depression that was still there: Wellbutrin, now all the way up to 450mg with no problems.

It's definitely more drugs than I would want (with an occasional Xanax--though my supply of that is dwindling and my pdoc has turned anti benzodiazepine like all the rest it seems now), but for a while now everything has been hunky-dory. So I'm all in favor of med cocktails and I do think you can feel which is doing what, if you don't add them all at once.