I use St. John's Wort (since last March) and I think it is working. I was pretty severe when I started it, but I wasn't willing to try prescription drugs and people were telling me that SJW worked for them. I avoided even SJW for a long time.

It is not without side effects, but I only had side effects when I overdosed. The side effects I had were numbness and tingling in my fingers and hypomania, and both went away when I got back to an appropriate dosage. There has only been one time since I have been using SJW when I got significantly depressed and I was taking too little SJW then (skipped it for one day then forgot it half the time for the next couple of days).

I have gel-caps that are 300 mg each and I take two per day, six days per week. I also use an herbal tea with SJW (800 mg per bag) but if I use the tea I have to not take the gel-caps. I make the tea as an iced tea, a quart at a time, and keep it in the refrigerator, but only one bag in the quart is SJW and the rest are peppermint or some other flavor. When I overdosed it was because I was making a quart with 4 bags of SJW and then drinking it all in one day. I did that like three days in a row. More than 900 mg in a day is a bad idea.
Wendy

<font color=green>Keep away from people who try to belittle your ambitions. Small people always do that, but the really great make you feel that, you, too, can become great. -Mark Twain</font color=green>