As far as I know, yes, meds can stop working after we take it for several years. I’d ask the Pdoc to change the dosages or the meds completely. However, your post showed that you live in a very unsupportive environment. Do you have a therapist that you can talk your issues with? I think you need more support and I’d consider talking to a therapist and joining a depression support group in your area. The right medications would make a huge difference but I think meds alone wouldn’t be enough without therapy. Send you hugs