Yes! When I had to change pdocs for insurance issues, he had me titrate my Trileptal down because he thought I was depressed and not bipolar. I became so irritable and snappy with everyone. Once I realized what was going on, I found a new pdoc who got me back to my original dosage and everything was fine. My body is so accustomed to this dosage that any minor change throws me off. I know it's higher than most (1800mgs), but it really is what keeps me sane and so I refuse to change it ever again. The most recent time was I was challenged was November. Just the next step down to 1500mg had me annoyed again. Never again.