I'm usually med compliant too. But like you, there have been times when I feel normal that I decide I'm cured and stop taking them. I've also considered myself to be an amateur pharmacologist when I'm feeling really bad and I adjust my own med cocktail. Neither approach works. I always, always feel worse. The depression always comes back with a vengeance when I stop talking my meds and I always regret it. I vowed after never to stop taking my meds again the last time I did it and so far so good. However, I do still tweak things on occasion. I just make sure I tell my pdoc.