I've tried quite a few different meds, mostly SSRI's, in different combinations and strengths and none of them really helped. They did help alleviate the brain fog when I am in really bad shape. I can't work with brain fog, so that definately helped. But I never really saw a big improvement with the depression or anxiety. I am going to see my doctor who has been prescribing for me and ask him to recommend a psychiatrist. I just want someone to talk to at the moment, not going to take any more drugs.