Lithium and Zyprexa made me gain around 52 pounds (24kg). It was really depressing me but I needed both meds to survive. Recently though I found Latuda and was able to reduce then stop the Zyprexa. It has only been a month and I have lost about 8 pounds. I do eat less but I haven't been exercising more so I guess it is mainly due to stopping Zyprexa. It is such a relief to be losing weigh instead of continuously gaining it. So yes, Bipolar has directly effected my weight through meds.