Wellbutrin is activating for me and has been excellent at combating my depression on several occasions. Without an AP or stabalizer, it can make me hypo. I get pretty intense increased anxiety for the first few weeks and then it levels off. I'm hoping my PDOC will add some Wellbutrin to my cocktail at my upcoming appt. I hope Latuda and Wellbutrin will be a good combo for you. Best wishes!